New clinical definition for epilepsy improves diagnosis accuracy
An expert task force has created a new definition for epilepsy that refines the scope of patients diagnosed with this brain disease. The study published in Epilepsia, a journal published by Wiley on behalf of the International League Against Epilepsy (ILAE), provides a greater level of detail to diagnose epilepsy by including individuals with two unprovoked seizures, and those with one unprovoked seizure and other factors that increase risk of seizure recurrence.
The 2005 report by the ILAE task force defined an epileptic seizure as “a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain” and epilepsy as “a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures, and by the neurobiologic, cognitive, psychological, and social consequences of this condition. The definition of epilepsy requires the occurrence of at least one epileptic seizure.”
“Why change the definition of epilepsy?” asks task force lead author Dr. Robert Fisher from Stanford University School of Medicine. “The 2005 definition does not allow a patient to outgrow epilepsy, nor does it take into account some clinicians’ views that epilepsy is present after a first unprovoked seizure when there is a high risk for another. The task force recommendation resolves these issues with the new, more practical, definition of epilepsy that is aimed at clinicians. However, some researchers might use criteria similar to those of the older definition to facilitate comparison with prior studies.”
The task force suggests that epilepsy is a disease of the brain defined as:
1. At least two unprovoked (or reflex) seizures occurring more than 24 hours apart; or
2. One unprovoked (or reflex) seizure and a probability of further seizures similar to the general recurrence risk (at least 60%) after two unprovoked seizures, occurring over the next 10 years; or
3. Diagnosis of an epilepsy syndrome.
“The burden of determining recurrence risk does not fall on the clinician. If information is not available on recurrence risk after a first seizure, then the definition defaults to the old definition,” adds Dr. Fisher. According to the article epilepsy is “resolved” in individuals who are past the applicable age of an age-dependent epilepsy syndrome, or those that have been free of seizures for the last 10 years and off anti-epileptic drugs (AEDs) for 5 years or more. The authors note that, the meaning of “resolved” is not identical to that of “remission” or “cure.”
“The published definitions were supported with factual data, but in some cases medical evidence did not exist and the task force used a “consensus” approach for these definitions,” explains Drs. Gary Mathern and Astrid Nehlig, Editors-in-Chief of Epilepsia. In these instances, the editors are asking readers’ opinions adding, “We encourage you to go to http://surveys.verticalresponse.com/a/show/1539433/ea840f4206/0 to share your feedback regarding the new definition of epilepsy.”
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This study is published in Epilepsia. Media wishing to receive a PDF of this article may contact .(JavaScript must be enabled to view this email address).
Full citation: “A Practical Clinical Definition of Epilepsy.” Robert S. Fisher, Carlos Acevedo, Alexis Arzimanoglou, Alicia Bogacz, J. Helen Cross, Christian E. Elger, Jerome Engel Jr, Lars Forsgren, Jacqueline A. French, Mike Glynn, Dale C. Hesdorffer, B.-I. Lee, Gary W. Mathern, Solomon L. Moshé, Emilio Perucca, Ingrid E. Scheffer, Torbjörn Tomson, Masako Watanabe, and Samuel Wiebe. Epilepsia; Published Online: April 14, 2014 (DOI: 10.1111/epi.12550).
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MORE than half of 20,000 young people questioned in a major survey said they would not date a person with epilepsy, a European conference on Epilepsy Research in Dublin has been told.
This was because the stigma of epilepsy remains a major issue in the public mind, according to Professor Ley Sander of UCL Institute of Neurology London. Speaking at the European Forum on Epilepsy Research at the Dublin Convention Centre today.
He also highlighted the fact that such stigma “often causes as much suffering as, or more than, the physical manifestations, and affects how people respond to the disease burden.”
The European Forum on Epilepsy Research brings together the principal stakeholders in the epilepsy community.
Professor Sander, who is also a leading figure in the UK Epilepsy Society organisation, said epilepsy was the commonest serious neurological condition affecting 60 million people worldwide.
He said the disease was globally distributed, with no racial or geographic barriers, involving a high risk of premature mortality plus a heavy burden to the individual, including stigmatisation.
In the developed world there were 50 new cases per 100,000 population while in resource-poor countries the figure was 100 new cases per 100,000 population.
About the Journal
Epilepsia is the leading, most authoritative source for current clinical and research results on all aspects of epilepsy. As the journal of the International League Against Epilepsy, subscribers every month will review scientific evidence and clinical methodology in: clinical neurology, neurophysiology, molecular biology, neuroimaging, neurochemistry, neurosurgery, pharmacology, neuroepidemiology, and therapeutic trials.
About the International League Against Epilepsy
The International League Against Epilepsy (ILAE) is the world’s preeminent association of physicians and health professionals working toward a world where no person’s life is limited by epilepsy. Since 1909 the ILAE has provided educational and research resources that are essential in understanding, diagnosing and treating persons with epilepsy. The ILAE supports health professionals, patients, and their care providers, governments, and the general public worldwide by advancing knowledge of epilepsy.
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