Occasional erratic heart rhythms appear to cause about one-fifth of strokes for which a cause is not readily established, according to research presented at the American Stroke Association’s International Stroke Conference 2012.

About one-third of survivors leave the hospital with the cause of their stroke still undetermined.

“Identifying and treating these patients for irregular rhythm could reduce the recurrence of stroke by 40 percent compared to reducing the risk by treating them with aspirin,” said Daniel J. Miller, M.D., the study’s first author and a senior staff neurologist at Henry Ford Hospital in Detroit, Mich. “The cause doesn’t make a difference if there isn’t a treatment, and recently two new medications – dabigatran and rivaroxaban – have been approved by the FDA to treat this problem.”

The study confirmed a 2008 report that found 13 of 56 patients (23 percent) whose heart rhythms were measured by automated monitors for 21 days had intermittent, or paroxysmal atrial fibrillation (PAF). Such episodes can last for a few seconds up to several days.

The 2008 study suggested that erratic beats of less than 30 seconds might indicate more prolonged episodes of PAF that lead to small blood clot formation in the hearts of patients with otherwise unidentified causes for their strokes. Since the study, stroke specialists have debated the importance of PAF to patients.

Some stroke centers, including Henry Ford Hospital, adopted the Mobile Cardiac Outpatient Monitoring™ (MCOT™) system as a method of identifying PAF.

Miller and his colleagues examined the medical records of 156 patients (half women) who had undergone monitoring no more than six months after a stroke or transient ischemic attack (TIA), most of them for 21 days. Ninety-seven percent were not taking prescription anticoagulation drugs.

Of the total, 27 patients (17.3 percent) had one or more PAF episodes during monitoring and the number increased significantly over time. In the first two days, 3.9 percent of the patients experienced an episode of PAF. The percentage rose to 9.2 percent after one week, 15.1 percent at two weeks and 19.5 percent by three weeks, after accounting for those that had stopped monitoring early.

Patients identified at study entry with premature atrial contractions — the most common type of erratic heartbeats — were 13.7 times more likely to have PAF than those without the rhythm problems. “That’s a very high risk,” Miller said.

Excluding TIA patients, the presence of premature atrial contractions in stroke survivors increased their risk of PAF to 17 times. Each one level increase in a patient’s National Institutes of Health Stroke Scale increased the risk of AF by 20 percent. The 42 point scale provides physicians a standardized method to assess a patient’s stroke-induced impairment.

The other risk factors applicable to stroke and TIA patients were:

  Being female. Women in the study had 6.2 times a man’s risk of PAF. In stroke patients alone, the risk was 4.6 times.
  Having a left atrium enlarged by 1 centimeter in diameter. This finding increased the AF risk 2.3 times.
  A reduction in blood pumped by the heart. People whose left ventricle expelled 10 percent less blood than a healthy heart had a 1.8 times risk.

“Patients with stroke of unknown origin should have at least 21 days of MCOT monitoring to reliably detect paroxysmal atrial fibrillation in order to reduce their risk of future stroke,” Miller said.

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Co-authors are: Muhib Khan, M.D.; Lonni Schultz, Ph.D.; Jennifer R. Simpson, M.D.; Andrew Russman, D.O.; and Mitsias Panayiotis, M.D., Ph.D. Author disclosures are on the abstract.

Statements and conclusions of study authors that are presented at American Stroke Association scientific meetings are solely those of the study authors and do not necessarily reflect association policy or position. The association makes no representation or warranty as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing science content.

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