Rice University bioengineering students responded to an ophthalmologist’s cry for help with a device to diagnose dry eye, the itching and burning sensation that results when a person doesn’t produce enough tears or the tears evaporate too quickly.

A team of five seniors made a portable unit that controls the air around a patient’s eyes so doctors can study and treat those who suffer from this painful condition.

Stephen Pflugfelder, the James and Margaret Elkins Chair and professor of ophthalmology at Baylor College of Medicine’s Cullen Eye Institute, approached Rice to invent a device to help clinicians standardize a testing regime for dry eye.

“He wanted a way to control temperature, humidity and air flow all around the eyes and record it over time so he could track changes in their dryness,” said Daniel Hays, a member of Team ClimaTears, the student group that included Austin Edwards, Amanda Shih, Anastasia Alex and Michelle Kerkstra.

The students’ solution incorporates a modified and padded set of laboratory goggles with embedded data sensors that monitor temperature, relative humidity, air flow and blink rate over an hour and a half. A cable carries data saved every 10 seconds to a small box that includes controls and conditioning equipment. A separate hose carries air to the goggles.

The goggles keep the humidity of air around the eyes between 40 and 15 percent - “about as low as we can go without hurting patients,” Alex said.

“We’re exacerbating the symptoms so doctors can see them,” Hays explained.

Normal patients will produce tears, he said, but those who suffer dry eye will exhibit symptoms, which will give clues about how to treat them. Follow-up sessions with the goggles will let doctors see how well the treatment is working.

“With this, we’re putting the power in the hands of clinicians, which is very appealing to them,” Shih said.

“We did a lot of research on the ocular test they currently perform to help us analyze the data we collected,” Alex said. “We know there’s still a lot to be done.”

“We hope our device will create a gold standard for diagnosis,” Kerkstra said.

The team and Pflugfelder spent two weeks this spring testing patients at the Alkek Eye Center in Houston and will continue this summer. The students hope the larger trial will lead to an academic paper - a fine reward for spending nearly 2,000 hours developing the goggles over the course of their final year at Rice.

Their work has already paid dividends. The students won the grand prize, $1,500, in the second annual Rice Alliance-George R. Brown School of Engineering Senior Design Elevator Pitch Competition last November, and more recently $500 for the Best Health-Related Engineering Design Project at the School of Engineering Design Showcase held April 14.

The team’s faculty advisers were Renata Ramos, a Rice lecturer in bioengineering, and Maria Oden, professor in the practice of engineering education and director of Rice’s Oshman Engineering Design Kitchen, where the goggles were developed.

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Video of the team demonstrating the ClimaTears device is available at http://www.youtube.com/watch?v=yw4iglYUZ8E

CAPTIONS

(Student wearing goggles)
Rice University senior Austin Edwards wears the modified, sensor-laden laboratory goggles designed by a Rice student engineering team as part of a device for the diagnosis of dry eye. (Credit Jeff Fitlow/Rice University)

(Team)
The Rice University student members of Team ClimaTears - clockwise from bottom left, Amanda Shih, Daniel Hays, Anastasia Alex, Austin Edwards and Michelle Kerkstra - have built a device to help create a gold standard for the diagnosis of dry eye. (Credit Jeff Fitlow/Rice University)

Located on a 285-acre forested campus in Houston, Texas, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is known for its “unconventional wisdom.” With 3,485 undergraduates and 2,275 graduate students, Rice’s undergraduate student-to-faculty ratio is less than 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice has been ranked No. 1 for best quality of life multiple times by the Princeton Review and No. 4 for “best value” among private universities by Kiplinger’s Personal Finance.

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