A University of Adelaide forensic pathologist has sounded a worldwide warning of the potential lethal dangers of herbal medicines if taken in large quantities, injected, or combined with prescription drugs.

A paper by Professor Roger Byard published in the US-based Journal of Forensic Sciences outlines the highly toxic nature of many herbal substances, which a large percentage of users around the world mistakenly believe are safe.

“There’s a false perception that herbal remedies are safer than manufactured medicines, when in fact many contain potentially lethal concentrations of arsenic, mercury and lead,” Professor Byard says.

“These substances may cause serious illnesses, exacerbate pre-existing health problems or result in death, particularly if taken in excess or injected rather than ingested.”

Professor Byard says there can also be fatal consequences when some herbal medicines interact with prescription drugs.

“As access to such products is largely unrestricted and many people do not tell their doctor they are taking herbal medicines for fear of ridicule, their contribution to death may not be fully appreciated during a standard autopsy.”

An analysis of 251 Asian herbal products found in United States stores identified arsenic in 36 of them, mercury in 35 and lead in 24 of the products.

In one documented case a 5-year-old boy who had ingested 63 grams of “Tibetan herbal vitamins” over a period of four years was diagnosed with lead poisoning. Another case involved a young boy with cancer of the retina whose parents resorted to a traditional Indian remedy that caused arsenic poisoning.

A herbal medicine known as Chan su, used to treat sore throats, boils and heart palpitations, contains the venomous secretions of Chinese toads, which can cause cardiac arrests or even comas, according to Professor Byard.

Other side effects of herbal medicines can include liver, renal and cardiac failure, strokes, movement disorders, muscle weakness and seizures.

“Herbal medicines are frequently mixed with standard drugs, presumably to make them more effective. This can also have devastating results,” Professor Byard says.

In his paper he cites the case of an epileptic patient on prescription medicine who had also ingested a Chinese herbal preparation and lapsed into a coma. Cushing syndrome, a hormonal disorder, has also been linked to the ingestion of steroids and herbal cures mixed together.

Some herbal medicines may also have a variety of effects on standard drugs, according to Professor Byard. St John’s Wort can reduce the effects of warfarin and cause intermenstrual bleeding in women taking the oral contraceptive pill.

Gingko and garlic also increase the risk of bleeding with anticoagulants and certain herbal remedies such as Borage Oil and Evening Primrose Oil lower the seizure threshold in epileptics.

Professor Byard says the American Society of Anesthesiologists has recommended its patients discontinue using herbal medicines at least two weeks before surgery because of the risks of herbal and drug interaction, including an increased chance of hemorrhaging.

Herbal medicines have become increasingly popular in western countries in recent years, with an estimated 30% of United States citizens using them, often without their doctor’s knowledge.

“Forensic pathologists the world over need to become more aware of the contribution that herbal medicines are playing in a range of deaths, that is not currently recognised,” Professor Byard says.

Roger Byard is the George Richard Marks Professor of Pathology within the School of Medical Sciences at the University of Adelaide.

Source:  University of Adelaide