‘‘High-glycemic’’ foods tied to diabetes risk

People who eat a lot of low-fiber and processed foods that quickly spike blood sugars may, not surprisingly, have a significantly higher risk of the most common form of diabetes, according to a new study.

“By raising blood sugar and demanding that the pancreas keep pumping more insulin, meal after meal, day after day, a high-glycemic diet can put people at risk over the edge,” said Dr. David Ludwig, who studies obesity at Boston Children’s Hospital but was not involved in the work.

The report analyzes 24 studies published since 1997 that tracked what 125,000 adults ate. The new study confirms links prior researchers made between those so-called high-glycemic foods - including white bread and potatoes - and diabetes.

Published in the American Journal of Clinical Nutrition, the new report from researchers at the University of California, Los Angeles, Oxford University in the UK and others found that the 125,000 studied adults daily ate an average of 139 grams of sugar or its equivalent.

According to the U.S. Centers for Disease Control and Prevention, about 8 percent of Americans have diabetes. More than 90 percent of those cases are type 2 diabetes, which prevents the body from properly using or producing the blood sugar-regulating hormone insulin.

The analysis did not pinpoint precisely how many of the 125,000 participants actually developed the disease, but for every additional 100 grams of sugar per 2,000 daily calories, people had a 45 percent higher risk of type 2 diabetes.

“It’s easy to get more than 100 grams, especially if you’re not being careful to choose the right kinds of foods,” research dietician Heidi Silver, of Vanderbilt University Medical Center in Nashville, who was not involved in the new study, told Reuters Health.

Low-glycemic foods include fish, meat, high-fiber fruits and vegetables, nuts, cheeses and other dairy products, brown rice and other unrefined grains. The glycemic load is calculated by multiplying the total of carbohydrate grams in a given food by its assigned glycemic index, a number that can be found in online tools.

It’s important for the general public to better understand what high-glycemic and low-glycemic mean, researchers said, and how to figure out their glucose intake. A very ripe banana, for example, has far more grams of sugar than one that’s still green. Eaten raw, rather than cooked, sweet potatoes have a low glycemic index.

There’s a “jungle of information and misinformation out there,” clinical dietician Kari Kooi of Methodist Hospital in Houston told Reuters Health.

“For instance, fiber (in prepackaged energy) bars is not the same thing as natural fiber you get in fruits and vegetables,” said Kooi, who was not involved in the current study. “That’s deceptive to consumers, who also may not realize that just having fiber…doesn’t necessarily mean the same thing as being low-glycemic.”

SOURCE: American Journal of Clinical Nutrition, online January 30, 2013

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Is there a dose-response relation of dietary glycemic load to risk of type 2 diabetes? Meta-analysis of prospective cohort studies Results: Among 24 prospective cohort studies identified by August 2012, the GL ranged from ∼60 to ∼280 g per daily intake of 2000 kcal (8.4 MJ). In a fully adjusted meta-analysis model, the GL was positively associated with RR of T2D of 1.45 (95% CI: 1.31, 1.61) for a 100-g increment in GL (P < 0.001; n = 24 studies; 7.5 million person-years of follow-up). Sex (P = 0.03), dietary instrument validity (P < 0.001), and ethnicity (European American compared with other; P = 0.04) together explained 97% of the heterogeneity among studies. After adjustment for heterogeneities, we used both funnel and trim-and-fill analyses to identify a negligible publication bias. Multiple influence, cumulative, and forecast analyses indicated that the GL-T2D relation tended to have reached stability and to have been underestimated. The relation was apparent at all doses of GL investigated, although it was statistically significant only at >95 g GL/2000 kcal. Conclusion: After we accounted for several sources of heterogeneity, findings from prospective cohort studies that related the GL to T2D appear robust and consistently indicate strong and significantly lower T2D risk in persons who consume lower-GL diets.   Geoffrey Livesey,   Richard Taylor,   Helen Livesey, and   Simin Liu

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