There is no evidence to link mildly elevated thyroid-stimulating hormone (TSH) levels to an increase in mortality among the elderly, according to a recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM). The findings suggest that reflexively treating mild elevations of TSH in those of advanced age is unnecessary.

TSH is a sensitive, commonly measured test to check thyroid function. TSH levels are inversely related to thyroid hormone levels – thyroid hormone levels below a set-point trigger an increase in TSH. Levels of TSH gradually increase during the aging process, which means that elderly patients are likely to be outside of standard reference ranges and could be labeled with the diagnosis of subclinical hypothyroidism.

“As increasing numbers of people live into their 80s and 90s, it is important to know how to manage their health, including thyroid function,” said Anne R. Cappola, MD, ScM of the University of Pennsylvania in Philadelphia, and lead author of the study. “Our study shows that a gradual increase in TSH occurs during healthy aging and that mild increases in TSH are not harmful in the oldest old.”

The study began in 1989-1992 and examined 5,888 men and women aged 65 and older. In 2005, 843 surviving participants who had thyroid function testing were examined for changes in physical and cognitive functions. Between 1992 and 2005, participants who were not taking thyroid medication at either visit had a 13 percent increase in TSH. Older participants (mean age 85 years) with increased TSH and subclinical hypothyroidism did not have a higher mortality rate; on the contrary, data suggested that having subclinical hypothyroidism could be protective. In addition, higher levels of thyroid hormone itself were associated with a higher risk of death.

“Our research presents the first data demonstrating longitudinal changes in thyroid function in a cohort of the oldest old,” said Cappola. “Our findings suggest that treating mild elevations in TSH in the elderly is unnecessary. Further studies are needed to determine the threshold levels of thyroid function that would benefit from intervention.”
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Other researchers working on the study include: Avantika C. Waring of the University of California at San Franscisco; Alice Arnold and Petra Buzkova of the University of Washington; Anne Newman of the University of Pittsburgh; and Calvin Hirsch of the University of California at Davis.

The article, “Longitudinal Changes in Thyroid Function in the Oldest Old and Survival: the Cardiovascular Health Study All-Stars Study,” appears in the November 2012 issue of JCEM.

Founded in 1916, The Endocrine Society is the world’s oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, The Endocrine Society’s membership consists of over 15,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Maryland.

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Aaron Lohr
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The Endocrine Society