In his article, “Pathoetiology of multiple sclerosis: are we barking up the wrong tree?”, Peter K. Stys of the Hotchkiss Brain Institute, University of Calgary, argues that while the majority of the medical research community currently approaches MS as an autoimmune disease (much like Lupus and Rheumatoid Arthritis), for which the trigger is the immune system attacking a particular part of the nervous system, the features of the disease are equally well explained by approaching MS as a neurodegenerative disease (such as Parkinson’s and Alzheimer’s), which is followed by an immune reaction to damage.

This may sound like a fine distinction, but it would totally change the approach taken in treating the disease, as one would try to stop the degeneration of the nervous system rather than damp down the immune system. Neurodegenerative diseases are characterized by the breaking down of the nervous system, and although immune cell infiltration and loss of the myelin sheath that insulates nerve fibres is the hallmark of MS, more recent studies indicate that neuronal structures are also damaged.

Dr. Stys argues that as current approaches have failed to produce effective treatments, the medical research community should look afresh at alternative explanations for the disease, in order to better understand how to treat MS.

To find out more about Faculty of 1000, please contact Eleanor Howell on +44 (0)20 7631 9129 or email .(JavaScript must be enabled to view this email address). For more information, visit http://f1000.com.

About F1000Prime Reports

F1000Prime Reports is an open access review journal from Faculty of 1000, the publisher of unique services that support and inform the work of life scientists and clinicians. F1000Prime Reports articles are peer-reviewed discussions of emergent themes, written or co-authored by F1000’s expert Faculty Members.

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Eleanor Howell
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44-020-763-19129
Faculty of 1000