Trigger of heroin withdrawal symptoms identified
Researchers have identified a protein called GAT-1 that appears to play a key role in the withdrawal symptoms experienced by people who stop using heroin and other “opioid” drugs, such as morphine and codeine. As such, GAT-1 could serve as a target for drugs designed to prevent withdrawal symptoms.
Using various lab techniques, Dr. Elena E. Bagley and colleagues, from the University of Sydney in Australia, showed that opioid withdrawal causes a small electrochemical current to form in nerve cells. Further analysis revealed that GAT-1 regulated this current.
The researchers’ findings appear in the scientific journal Neuron.
Blocking GAT-1 with certain drugs prevented the overstimulation of nerve cells that normally occurs during opioid withdrawal, the investigators report.
Anti-GAT-1 drugs are already being used to treat epilepsy, the authors note, and may prove useful opioid withdrawal as well.
SOURCE: Neuron, February 3, 2005.
Revision date: June 21, 2011
Last revised: by Andrew G. Epstein, M.D.