Infection with the human immunodeficiency virus type I (HIV) is a multisystem disease. Manifestations of pulmonary, gastrointestinal, neurologic, hematologic, and oncologic disease are well described in the literature, owing mainly to their high prevalence and often dramatic modes of presentation. In contrast, HIV-related renal, cardiac, endocrine, and rheumatologic diseases are more insidious in presentation. As overall survival of HIV-infected individuals continues to improve and therapeutic regimens become more sophisticated, clinicians will undoubtedly encounter disorders of the latter organ systems with increasing frequency.