Calcium supplements are widely taken by women for bone health. Previous studies have suggested that calcium supplements may increase risk of cardiovascular disease, but the data has been inconsistent. A new study by researchers at Brigham and Women’s Hospital (BWH) did not find that calcium supplement intake increases risk of cardiovascular disease in women.

The study is published online this month in Osteoporosis International.

Researchers examined supplemental calcium use and incident cardiovascular disease in a prospective cohort study of 74,245 women in the Nurses’ Health Study. The women did not have cardiovascular disease or cancer at the start of the study. They were followed for 24 years to document risk of developing heart attack and stroke. Calcium supplement intake was assessed every four years.

“Our study has several distinct strengths compared to prior studies including the large number of participants, long-term follow-up, large number of cardiovascular events that were confirmed by medical record review, detailed information about diet and other cardiovascular disease risk factors, and repeated assessment of calcium supplement use over the 24-year follow up period,” said Julie Paik, MD, MPH, BWH Channing Division of Network Medicine, Department of Medicine, lead study author.

The researchers found that at the start of the study, women who took calcium supplements had higher levels of physical activity, smoked less, and had lower trans fat intake compared to women who did not take calcium supplements. During the 24 years of follow-up, there were 2,709 heart attacks and 1,856 strokes.

“Based on our findings, additional prospective cohort studies examining potential cardiovascular disease risk associated with calcium supplement use are needed,” said Paik. “Future randomized trials of calcium supplementation, if conducted, should be designed to optimize assessment of cardiovascular events.”

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This research was supported by the National Institutes of Health (HL092947, HL34594, HL088521, DK091417, DK100447 and CA087969).

Brigham and Women’s Hospital (BWH) is a 793-bed nonprofit teaching affiliate of Harvard Medical School and a founding member of Partners HealthCare. BWH has more than 3.5 million annual patient visits, is the largest birthing center in Massachusetts and employs nearly 15,000 people. The Brigham’s medical preeminence dates back to 1832, and today that rich history in clinical care is coupled with its national leadership in patient care, quality improvement and patient safety initiatives, and its dedication to research, innovation, community engagement and educating and training the next generation of health care professionals. Through investigation and discovery conducted at its Biomedical Research Institute (BRI), BWH is an international leader in basic, clinical and translational research on human diseases, more than 1,000 physician-investigators and renowned biomedical scientists and faculty supported by nearly $650 million in funding. For the last 25 years, BWH ranked second in research funding from the National Institutes of Health (NIH) among independent hospitals. BWH continually pushes the boundaries of medicine, including building on its legacy in transplantation by performing a partial face transplant in 2009 and the nation’s first full face transplant in 2011. BWH is also home to major landmark epidemiologic population studies, including the Nurses’ and Physicians’ Health Studies and the Women’s Health Initiative. For more information, resources and to follow us on social media, please visit BWH’s online newsroom.

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Marjorie Montemayor-Quellenberg
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Brigham and Women’s Hospital