Aerobic exercise training appears safe for patients with heart failure and was associated with a modest reduction in the risk of death and hospitalization, with some improvement in quality of life, according to two articles in the April 8 issue of JAMA.

Heart failure is a major and increasingly common cardiovascular syndrome, and is the end result of many cardiovascular disorders. In the United States, an estimated 5 million patients have heart failure and an additional 500,000 new cases are diagnosed annually. Many patients treated with drug and device therapies often still have breathing difficulties and fatigue, diminished exercise tolerance, reduced quality of life, recurrent hospitalizations and premature death, according to background information in the article. Guidelines recommend that exercise training be considered for medically stable outpatients with heart failure, but there have remained concerns regarding safety and uncertainty about clinical outcomes.

Christopher M. O’Connor, M.D., of Duke University School of Medicine, Durham, N.C., and colleagues working with Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION), examined whether aerobic-type exercise training reduces all-cause death or all-cause hospitalization in patients with medically stable chronic heart failure due to systolic dysfunction (impaired contraction of the heart). Patients in the study (n = 2,331; median [midpoint] age, 59 years) were randomized to usual care plus aerobic exercise training (that consisted of 36 sessions of supervised aerobic exercise training [walking, treadmill or stationary cycling] three times per week followed by prescribed home-based training at the same intensity 5 times per week) or usual care alone (that included optimal medical therapy and a recommendation for regular physical activity). Exercise adherence decreased from a median of 95 minutes per week during months 4 through 6 of follow-up to 74 minutes per week during months 10 through 12. Median follow-up was 30 months.

During follow-up, 759 patients in the exercise training group (65 percent) and 796 patients in the usual care group (68 percent) died or were hospitalized. In the primary analysis, exercise training resulted in a nonsignificant reduction in the primary end point of all-cause death or hospitalization. There was no significant difference in the number of deaths in the exercise training group (16 percent) vs. in the usual care group (17 percent). Exercise training had a nonsignificant reduction in the combined end point of cardiovascular death or cardiovascular hospitalization in the main analysis in the exercise training group (55 percent) vs. in the usual care group (58 percent). There was a nonsignificant reduction in cardiovascular death or heart failure hospitalization in the exercise training group vs. in the usual care group.

After adjusting for highly prognostic predictors of the primary end point, exercise training was found to significantly reduce the incidence of all-cause death or all-cause hospitalization by 11 percent and cardiovascular death or heart failure hospitalization by 15 percent. Other adverse events were similar between the groups.

“The change from a nonsignificant to a significant result after adjustment for strongly predictive factors is unusual in large clinical trials, but can occur when the treatment differences are close to significance. The overall interpretation of the results, then, is that this structured exercise training intervention had at best a modest effect on clinical end points in a large cohort of patients,” the authors write.

“Based on the safety of exercise training and the modest reductions in clinical events …, the HF-ACTION results support a prescribed exercise training program for patients with reduced left ventricular function and heart failure symptoms in addition to evidence-based therapy,” the researchers conclude.

(JAMA. 2009;301[14]:1439-1450. Available pre-embargo to the media at http://www.jamamedia.org)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Exercise Training Improves Health Status of Heart Failure Patients

Patients with heart failure who participated in aerobic exercise training had modest improvements in self-reported health status compared to those patients who did not have exercise training, according to an article appearing the April 8 issue of JAMA.

Patients with heart failure often experience diminished health status, including reductions in physical and social functioning and other dimensions of health-related quality of life. “Pharmacological and device interventions and disease management programs for heart failure have provided little or modest improvements in health-related quality of life. The extent to which exercise training in addition to optimal evidence-based therapy improves patients’ health status is unknown,” the authors write.

Kathryn E. Flynn, Ph.D., of Duke University School of Medicine, Durham, N.C., and colleagues examined the effects of exercise training on health status among patients with heart failure who were participants of HF-ACTION. Health status was assessed using the Kansas City Cardiomyopathy Questionnaire (KCCQ), a 23-item self-administered disease-specific survey. The KCCQ is scored from 0 to 100, with higher scores representing better health status. HF-ACTION compared scores on the KCCQ overall summary scale and key subscales (i.e., physical limitations, symptoms, quality of life and social limitations) between randomized groups. Median follow-up was 2.5 years.

At 3 months, usual care plus exercise training led to greater improvement in the KCCQ overall summary score compared with usual care alone. Neither group experienced significant changes in KCCQ scores after 3 months, resulting in a sustained, greater improvement overall for the exercise group. At 12 months, 53 percent of patients in the exercise training group had a clinically noticeable improvement from the beginning of the trial compared with 33 percent in the usual care group.

Results for the KCCQ subscales were similar to the results for the overall summary scale. After adjusting for the cause of heart failure, there was a significant overall treatment effect on physical limitations, symptoms, quality of life and social limitations.

“The results demonstrate that participation in an exercise training program provides a modest but statistically significant improvement in patient-reported health status compared with usual care. The clinical meaningfulness of the magnitude of average change requires further study,” the authors conclude.

(JAMA. 2009;301[14]:1451-1459. Available pre-embargo to the media at http://www.jamamedia.org)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Source: American Medical Association (AMA)