Pure mediastinal seminomas are curable in the large majority of patients, even when metastatic at the time of diagnosis. These tumors are highly sensitive to radiation therapy and to combination chemotherapy, and selection of…

Prior to the development of effective cisplatin-based chemotherapy, no effective therapy was available for nonseminomatous mediastinal germ cell tumors. Local treatment modalities were ineffective because of the high percentage of patients with metastatic…

Klinefelter Syndrome Klinefelter syndrome is a relatively common chromosomal abnormality characterized by hypogonadism, azoospermia, and elevated gonadotropin levels in association with a 47,XXY karyotype. A slightly increased incidence of…