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Tumors of the scrotal skin are rare. The most common benign lesion is a sebaceous cyst. Squamous cell carcinoma is the most common malignant tumor of the scrotum, although rare cases of melanoma,…

Primary tumors of the epididymis are rare and are most commonly benign. Adenomatoid tumors of the epididymis are the most common and typically occur in the third and…

Secondary tumors of the testis are rare. Three categories are considered: lymphoma, leukemia, and metastatic tumors.

Survival in testicular cancer has improved dramatically over the past several years, reflecting the continuing improvement and refinement in combination chemotherapy.

For seminoma treated by orchiectomy and radiotherapy, the 5-year…

Inguinal exploration with cross-clamping of the spermatic cord vasculature and delivery of the testis into the field is the mainstay of exploration for a possible testis tumor. If cancer cannot…

An incorrect diagnosis is made at the initial examination in up to 25% of patients with testicular tumors and may result in delay in treatment or a suboptimal surgical…

A. Symptoms
The most common symptom of testicular cancer is a painless enlargement of the testis. Enlargement is usually gradual, and a sensation of testicular heaviness is not…

With the exception of choriocarcinoma, which demonstrates early hematogenous spread, germ cell tumors of the testis typically spread in a stepwise lymphatic fashion. Lymph nodes of…

A. Seminoma (35%)
Three histologic subtypes of pure seminoma have been described. However, stage for stage, there is no prognostic significance to any of these subtypes. Classic seminoma…

Numerous classification systems have been proposed for germ cell tumors of the testis. Classification by histologic type proves to be the most useful with respect to treatment. The 2…

Three-dimensional computed tomography (CT) colonography, also known as virtual colonoscopy, is an accurate screening method for colorectal cancer, according to a study published in the November issue…

Pure mediastinal seminomas are curable in the large majority of patients, even when metastatic at the time of diagnosis. These tumors are highly sensitive to radiation therapy and to combination chemotherapy, and selection of…

Prior to the development of effective cisplatin-based chemotherapy, no effective therapy was available for nonseminomatous mediastinal germ cell tumors. Local treatment modalities were ineffective because of the high percentage of patients with metastatic…

Klinefelter Syndrome Klinefelter syndrome is a relatively common chromosomal abnormality characterized by hypogonadism, azoospermia, and elevated gonadotropin levels in association with a 47,XXY karyotype. A slightly increased incidence of…

Vitamin D may help curb breast cancer progression, suggests a small study published ahead of print in the Journal of Clinical Pathology.

The authors reach their conclusion from a…

Differences in estrogen levels may partially explain the ethnic disparities in breast cancer rates among U.S. women, new research suggests.

In a study of more than 700 postmenopausal women,…

Ovarian cysts do not increase the risk of breast cancer, according to the results of a review study. In fact, such cysts were associated with a 30-percent decreased risk…

A team of University of Iowa Health Care researchers has launched an important clinical trial of a novel therapeutic that may eventually lead to new treatments for men diagnosed with…

Researchers have known that a woman’s natural hormone levels can affect her risk of developing breast cancer. A new study from the University of Southern…

A new breast cancer ‘wonder drug’ could be available to British women within a matter of months.

The drug Tykerb taken once a day, at home,…

Moderate but regular exercise can help women avoid some of the side-effects of radiation treatment for breast cancer, U.S. researchers reported on Monday.

Researchers studied 20 women with breast cancer,…

Researchers at University of Utah’s Huntsman Cancer Institute have discovered a new target for possible future colon cancer treatments -  a molecule that is implicated in 85 percent of colon…

The risk of ovarian cancer is increased in women who use unopposed estrogen for 10 years or more, and in those taking estrogen and progestin for 5 years or more,…

Scientists at the UVa Cancer Center have studied melanoma tumors from patients at various stages of the disease over the last few years. They discovered that more than half of these…