A new study presented at the Annual Scientific Meeting of the American Urological Association (AUA) suggests that firefighters may be at an increased risk of developing transitional cell carcinoma (TCC, or bladder cancer) and should be considered for routine annual screening. Currently, no guidelines exist for regular TCC screening.

Researchers from the University of California, San Francisco presented their study to the media during a special press conference on May 19, 2008 at 3:30 p.m.

It is well known that prolonged exposure to certain environmental pollutants and chemicals puts humans at a major risk for developing bladder cancer. As the body absorbs carcinogenic chemicals, such as cigarette smoke, the chemicals are transferred to the blood, filtered out by the kidneys and expelled from the body through the urine. Greater concentrations of chemicals in the urine can damage the endothelial lining of the bladder and increase a patient’s odds of developing transitional cell carcinoma (TCC). Firefighters, who are regularly exposed to smoke and chemical fumes, may be at a higher risk for developing the disease than other groups.

Researchers explored this possibility in a screening study of 1,286 active and retired San Francisco firefighters. From August 2006 to March 2007, the subjects – mean age 45 (SD+9.7) – participated in voluntary urine dipstick testing and point-of-care NMP-22 testing. 93 Patients tested positive for hematuria and six tested positive for NMP-22. These 99 patients were referred for upper tract imaging, cystoscopy and urine cytology. Of the group, a single firefighter tested positive for both NMP-22 and hematuria, with two patients – both retired firefighters – ultimately diagnosed with TCC.

The age and sex-adjusted incidence for TCC is 36 per 100,000. These findings represent a higher incidence, suggesting that retired firefighters may be a high-risk group.

In addition to the author, Anthony Y. Smith, M.D., a spokesman for the AUA, will be on hand to provide expert commentary on the study.

NOTE TO REPORTERS: Experts are available to discuss these studies outside normal briefing times. To arrange an interview with an expert, please contact the AUA Communications Office at the number above or e-mail Wendy Waldsachs Isett at .(JavaScript must be enabled to view this email address).

Greene KL, Konety BR, Stoller ML: Results from the San Francisco Firefighters Bladder Cancer Screening Study. J Urol, suppl., 2008; 179: 323, abstract 937.

About the American Urological Association: Founded in 1902 and headquartered near Baltimore, Maryland, the American Urological Association is the pre-eminent professional organization for urologists, with more than 15,000 members throughout the world. An educational nonprofit organization, the AUA pursues its mission of fostering the highest standards of urologic care by carrying out a wide variety of programs members and their patients, including UrologyHealth.org, an award-winning on-line patient education resource, and the American Urological Association Foundation, Inc

Contact: Wendy Waldsachs Isett, AUA
410-689-3932, .(JavaScript must be enabled to view this email address)
AUA 2008: RETIRED FIREFIGHTERS COULD BE AT INCREASED RISK FOR DEVELOPING BLADDER CANCER