In a study of more than 36,000 women, researchers observed that smokers can reduce their risk of developing lung cancer by being physically active. However, they strongly caution that any relative benefit is dwarfed by the benefits gained from quitting smoking.

The researchers, from the Universities of Minnesota and Pennsylvania, report in the December issue of Cancer Epidemiology Biomarkers & Prevention that a high level of physical activity in women who smoked reduced their relative risk of developing lung cancer by 72 percent. Moderate activity among smokers was associated with a 65 percent risk reduction, and lower relative risks were also seen in former smokers who had moderate or high activity levels.

While this may sound like welcome news to female smokers who don’t want to quit, the investigators emphasize that the absolute risk of developing lung cancer is still much greater in current and former smokers regardless of activity level.

“The most important thing a smoker can do to reduce risk is to quit smoking. That said, exercising and being active can offer a marginal change in risk,” said the study’s lead author, Kathryn Schmitz, Ph.D. an assistant professor at the University of Pennsylvania. Schmitz worked on the study with a team of researchers while on faculty at the University of Minnesota.

In other words, she says, a physically active smoker has a 35 percent lower risk of lung cancer than a sedentary smoker, but if both smokers quit, they would both reduce their risk by as much as 10- or 11-fold. “Smokers who exercise are at a 35 percent lower risk of developing lung cancer relative to smokers who don’t exercise, but if you smoke at all, your risk of developing lung cancer is 10- to 11- fold higher than if you didn’t smoke.”

“The helpful message from this study is that if a smoker is having trouble quitting, exercise can be a first step toward better health,” says Schmitz.

The findings were derived from the Iowa Women’s Health Study, which in 1986 began to follow almost 42,000 women between the ages of 55 and 69. Over the years, five questionnaires were sent to the participants who recorded their smoking status and physical activity among other variables. This analysis, which began in 2002, included 36,410 participants, including 777 women diagnosed with the cancer. Among this group, 125 were non-smokers, 177 were former smokers, and 475 were current smokers.

Compared to women who were physically active, women with a low physical activity level at the baseline analysis were more likely to smoke, less likely to have a high school education and more likely to be obese.

Among smokers, the most number of cancer cases (324) were seen among women who currently smoked and had low activity, and the lowest number (40) was in the group of women who formerly smoked and were highly active. Compared to never smokers, current and former smokers had proportionally more squamous cell and small-cell lung cancer, which can be harder to treat than other subtypes.

Researchers don’t know why activity could lower lung cancer risk, but suggest that improved pulmonary function may reduce both the concentration of carcinogenic particles in the smoker’s airway and the extent to which they are deposited in the lungs. They also theorize that exercise training improves immune function and reduces the inflammatory responses that can impact cancer development.

“This may be useful information for smokers who are not currently willing to attempt smoking cessation or have recently failed a quit attempt,” says Schmitz. “But even if there was a significant risk reduction, quitting smoking is unarguably the most important action a person can take for reduction of lung cancer risk.”

The study was funded by the National Cancer Institute.

The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, AACR is the world’s oldest and largest professional organization dedicated to advancing cancer research. The membership includes more than 24,000 basic, translational, and clinical researchers; health care professionals; and cancer survivors and advocates in the United States and more than 70 other countries. AACR marshals the full spectrum of expertise from the cancer community to accelerate progress in the prevention, diagnosis and treatment of cancer through high-quality scientific and educational programs. It funds innovative, meritorious research grants. The AACR Annual Meeting attracts more than 17,000 participants who share the latest discoveries and developments in the field. Special Conferences throughout the year present novel data across a wide variety of topics in cancer research, treatment, and patient care. AACR publishes five major peer-reviewed journals: Cancer Research; Clinical Cancer Research; Molecular Cancer Therapeutics; Molecular Cancer Research; and Cancer Epidemiology, Biomarkers & Prevention. Its most recent publication, CR, is a magazine for cancer survivors, patient advocates, their families, physicians, and scientists. It provides a forum for sharing essential, evidence-based information and perspectives on progress in cancer research, survivorship, and advocacy.

Source: American Association for Cancer Research (AACR)