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Although abnormalities of insulin secretion in the pathophysiology of diabetes have often been neglected, they occur already early during the disease and can often already be demonstrated in subjects with normal glucose tolerance (first-degree relatives…

Insulin receptors are also expressed throughout the brain with particularly high concentrations in the hypothalamus, the hippocampus, and the cortex.

In humans, however, positron emission tomography (PET) studies repeatedly…

Insulin resistance is present when the biological effects of insulin are subnormal for both glucose disposal in skeletal muscle and suppression of endogenous glucose production primarily in liver.

In the fasting state, however, muscle…

Pre-mixed insulin analogues, a modified form of conventional pre-mixed human insulin, are more effective than long-acting analogues for controlling high blood sugar levels after meals in patients…

People with type 2 diabetes who took part in a multi-pronged weight management program lost weight and were able to keep it off long-term, new research shows.

What’s more, individuals who…

Each patient with type 2 diabetes needs individual advice and structured training by his or her physician and other members of the healthcare team, to enable them to translate the principles of…

Individuals with diabetes should be advised about the importance of acquiring daily vitamin and mineral requirements from natural food sources. Regular consumption of…

A few studies suggest that persons with type 2 diabetes have an increased need for protein during moderate hyperglycemia,  and an altered adaptive mechanism…

The primary goal regarding dietary fat intake in individuals with type 2 diabetes is to decrease intake of saturated fatty acids.  Compared with the…