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Crohn’s disease, a common inflammatory disorder of the intestinal tract, can have devastating consequences for a patient’s quality of life and is notoriously hard to treat successfully,…

With no laboratory test available to diagnose functional gastrointestinal disorders, proper diagnostic criteria are critical for clinicians to make an accurate determination of what ails their patients.

A study led by the Hasbro Children’s Hospital Division of Pediatric Gastroenterology, Nutrition and Liver Diseases found that the incidence of inflammatory bowel…

New research suggests that Helicobacter pylori (H. pylori) infection of the stomach, which occurs in about half of the world’s population and can cause peptic ulcers and…

Everyone has suffered from it. It’s ranged from mild to severe. It’s a condition that’s most-often described in a whisper.

Diarrhea.

Severe cases of diarrhea, however,…

Investigators at Children’s Hospital Los Angeles have found that a common therapeutic target for the treatment of inflammatory bowel disease (IBD) may actually protect against intestinal inflammation…

Azathioprine is a pro-drug that is converted into 6-mercaptopurine (6-MP)  and is subsequently metabolized by one of three different enzymes to form either active or inactive metabolites .

There is substantial inter-individual variation…

Glucocorticoids are highly effective for the short- term control of Crohn’s disease-related symptoms, but they are less effective for maintenance of remission, and have significant adverse effects that preclude safe long-term administration.

They work by…

Integrins are glycoproteins expressed on the surface of circulating leukocytes and mediate their adhesion to the vascular endothelium and their subsequent migration into adjacent tissue.

Anti- integrin therapies have been developed to selectively…

Antibiotics have a role in treating infectious complications of Crohn’s disease, including perianal and intra-abdominal abscesses, and in the longer term management of perianal fistulizing disease, and prevention of recurrence after ileocecal resection. Antibiotics may also…

TNF- α  is a pro-inflammatory cytokine that plays a pivotal role in the pathogenesis of IBD and has been found in increased concentrations in the mucosa and stool of patients with…

Treatment options for Crohn’s disease have been developing and expanding rapidly over the past 10 years. Multiple classes of medications are currently available to treat Crohn’s disease, including 5-aminosalicylates…

To understand the historical evolution of the disease, a review of its initial definition is critical. In 1932, Crohn, Ginzburg, and Oppenheimer identified 14 cases of inflammatory disease…

The natural history of Crohn’s disease involves fiuctuating periods of disease quiescence punctuated by episodes of exacerbation.  Cumulative bowel injury occurs over time with chronic smoldering inflammation and is accelerated by disease flares such…

Methotrexate is a structural analogue of folic acid that competitively inhibits its binding to its receptors and has demonstrated effectiveness for treating several autoimmune diseases,  including rheumatoid arthritis and psoriasis.  Possible mechanisms of its anti-inflammatory…

Crohn,  Ginzburg,  and Oppenheimer all graduated from Columbia University’s College of Physicians and Surgeons and subsequently succeeded in becoming house staff at the Mount Sinai Hospital. Their…

There is no doubt that the existence of Crohn’s disease has pre-dated our ability to understand and define it. In fact, a precise definition continues to elude us to this day, relying…

A natural compound called limonene, which is found in oranges and lemons, could be indicative in early-stage diagnosis of liver disease, according to research published in…

Intra-abdominal fat cells may contribute to the development and progression of inflammatory bowel disease (IBD), according to a study1 published in Cellular and Molecular Gastroenterology and Hepatology, the basic…

A new review published in the Cochrane Library, indicates that eradicating Helicobacter pylori bacterium - the main cause of stomach ulcers - with a…

Two new studies led by researchers from the Farncombe Family Digestive Health Research Institute at McMaster University show that transplantation of fecal matter may be a useful tool…

Around half of the global population is chronically infected with the stomach bacterium Helicobacter pylori, almost 1 percent of whom go on to develop gastric adenocarcinoma, one of…

Modifying the small white blood cells that protect against disease might help treat immune disorders, according to a study¹ published in Cellular and Molecular Gastroenterology and Hepatology, the basic…

A fifty-fold between-country difference in rates of paracetamol-induced acute liver failure that leads to liver transplant (ALFT) has been revealed by a study that compared patient…

Bowel cancer is often driven by mutations in one of several different genes, and a patient can have a cancer with a different genetic make-up to…