Also check Lung cancer, small cell

Definition

Non-small cell lung cancer is a disease in which the cells of the lung tissues grow uncontrollably and form tumors.

Description

There are two kinds of lung cancers, primary and secondary. Primary lung cancer starts in the lung itself, and is divided into small cell lung cancer and non-small cell lung cancer. Small cell lung cancers are shaped like an oat and called oat-cell cancers; they are aggressive, spread rapidly, and represent 20% of lung cancers. Nonsmall cell lung cancer represents almost 80% of all primary lung cancers. Secondary lung cancer is cancer that starts somewhere else in the body (for example, the breast or colon) and spreads to the lungs.

The lungs
The lungs are located along with the heart in the
chest cavity. The lungs are not simply hollow balloons but have a very organized structure consisting of hollow tubes, blood vessels and elastic tissue. The hollow tubes, called bronchi, are highly branched, becoming smaller and more numerous at each branching. They end in tiny, blind sacs made of elastic tissue called alveoli. These sacs are where the oxygen a person breathes in is taken up into the blood, and where carbon dioxide moves out of the blood to be breathed out.

Normal, healthy lungs are continually secreting mucus that not only keeps the lungs moist, but also protects the lungs by trapping foreign particles like dust and dirt in breathed air. The inside of the lungs is covered with small hairlike structures called cilia. The cilia move in such a way that mucus is swept up out of the lungs and into the throat.

Lung cancer
Most lung cancers start in the cells that line the bronchi, and can take years to develop. As they grow larger they prevent the lungs from functioning normally.
The tumor can reduce the capacity of the lungs, or block the movement of air through the bronchi in the lungs. As a result, less oxygen gets into the blood and patients feel short of breath. Tumors may also block the normal movement of mucus up into the throat. As a result, mucus builds up in the lungs and infection may develop behind the tumor. Once lung cancer has developed, it frequently spreads to other parts of the body.

The speed at which non-small cell tumors grow depends on the type of cells that make up the tumor. The following three types account for the vast majority of non-small cell tumors:

• Adenocarcinomas are the most common and often cause no symptoms. Frequently they are not found until they are advanced.
• Squamous cell carcinomas usually produce symptoms because they are centrally located and block the lungs.
• Undifferentiated large cell and giant cell carcinomas tend to grow rapidly, and spread quickly to other parts of the body.

Demographics

Worldwide, lung cancer is the most common cancer in males, and the fifth most common cancer in women.
The worldwide mortality rate for patients with lung cancer is 86%. In the United States, lung cancer is the leading cause of death from cancer among both men and women. The World Health Organization estimates that the worldwide mortality from lung cancer will increase to three million by the year 2025. Of those three million deaths, almost two and a half million will result from non-small cell lung cancer.

The incidence of lung cancer is beginning to fall in developed countries. This may be a result of antismoking campaigns. In developing countries, however, rates continue to rise, which may be a consequence of both industrialization and the increasing use of tobacco products.

Causes and symptoms

Causes
Tobacco smoking accounts for nearly 90% of all lung cancers. Giving up tobacco can prevent most lung cancers. Smoking marijuana cigarettes is considered another risk factor for cancer of the lung. Second hand smoke also contributes to the development of lung cancer among nonsmokers.

Certain hazardous materials that people may be exposed to in their jobs have been shown to cause lung cancer. These include asbestos, coal products, and radioactive substances. Air pollution may also be a contributing factor. Exposure to radon, a colorless, odorless gas that sometimes accumulates in the basement of homes, may cause lung cancer in a tiny minority of patients. In addition, patients whose lungs are scarred from other lung conditions may have an increased risk of developing lung cancer.

Symptoms
Lung cancers tend to spread very early, and only 15% are detected in their early stages. The chances of early detection, however, can be improved by seeking medical care at once if any of the following symptoms appear:

• a cough that does not go away
• chest pain
• shortness of breath
• recurrent lung infections, such as bronchitis or pneumonia
• bloody or brown-colored spit or phlegm (sputum)
• persistent hoarseness
• significant weight loss that is not due to dieting or vigorous exercise; fatigue and loss of appetite (anorexia)
• unexplained fever

Although these symptoms may be caused by diseases other than lung cancer, it is important to consult a doctor to rule out the possibility of lung cancer. If lung cancer has spread to other organs, the patient may have other symptoms such as headaches, bone fractures, pain, bleeding, or blood clots.

Diagnosis

Physical examination and diagnostic tests

The doctor will first take a detailed medical history and assess risk factors. During a complete physical examination the doctor will examine the patient’s throat to rule out other possible causes of hoarseness or coughing, and will listen to the patient’s breathing and chest sounds.

If the doctor has reason to suspect lung cancer, particularly if the patient has a history of heavy smoking or occupational exposure to irritating substances, a chest x ray may be ordered to see if there are any masses in the lungs. Special imaging techniques, such as computed tomography (CT) scans or magnetic resonance imaging (MRI), may provide more precise information about the size, shape, and location of any tumors.

Sputum analysis
Sputum analysis is a noninvasive test that involves microscopic examination of cells that are coughed up from the lungs. This test can diagnose at least 30% of lung cancers, even if tumors are not visible on chest x rays. In addition, the test can detect cancer in its very early stages, before it spreads to other regions. The sputum test does not provide any information about the location of the tumor.

Lung biopsy
Lung biopsy is the most definitive diagnostic tool for cancer. It can be performed in three different ways. Bronchoscopy involves the insertion of a slender, lighted tube, called a bronchoscope, down the patient’s throat and into the lungs. This test allows the doctor to see the tubes inside the lungs, and to obtain samples of lung tissue. If a needle biopsy is to be performed, the location of the tumor is first identified using a computerized tomography (CT) scan or magnetic resonance imaging (MRI). The doctor then inserts a needle through the chest wall and collects a sample of tissue from the tumor. In the third procedure, known as surgical biopsy, the chest wall is opened up and a part of the tumor, or all of it, is removed. A doctor who specializes in the study of diseased tissue (a pathologist) examines the tumor to identify the cancer’s type and stage.

Treatment team
The treatment team for patients with non-small cell lung cancer will depend on which treatment strategy is followed. For patients that are treated surgically, a thoracic surgeon will perform the procedure. These surgeons specialize in operating inside the chest cavity.

Patients who require radiation therapy will be seen by a radiation oncologist. Patients who need chemotherapy will see a hematologist or oncologist. Both are doctors who specialize in cancer treatment. Chemotherapy is usually administered by oncology nurses that specialize in caring for cancer patients.

Clinical staging, treatments, and prognosis

Staging
Treatment for non-small cell lung cancer depends primarily on the stage of the cancer. Staging is a process that tells the doctor if the cancer has spread and the extent of its spread. The most commonly used treatments are surgery, radiation therapy, and chemotherapy.

Non-small cell lung cancer has six stages:

• Occult carcinoma. Cancer cells have been found in the sputum, but no tumor has yet been found.
• Stage 0. A small group of cancerous cells have been found in one location.
• Stage I. The cancer is only in the lung and has not spread anywhere else.
• Stage II. The cancer has spread to nearby lymph nodes.
• Stage III. The cancer has spread to more distant lymph nodes, and/or other parts of the chest like the diaphragm.
• Stage IV. The cancer has spread to other parts of the body.

Surgery
Surgery is the standard treatment for the earlier stages of non-small cell lung cancer. The surgeon will decide on the type of surgery, depending on how much of the lung is affected. There are three different types of surgical procedures:

• Wedge resection is the removal of a small part of the lung.
• Lobectomy is the removal of one lobe of the lung. (The right lung has three lobes and the left lung has two lobes.)
• Pneumonectomy is the removal of an entire lung.

Lung surgery is a major procedure and patients can expect to experience pain, weakness in the chest, and shortness of breath. Air and fluid collect in the chest after surgery. As a result, patients will need help to turn over, cough, and breathe deeply. Patients should be encouraged to perform these activities because they help get rid of the air and fluid and speed up recovery. It can take patients several months before they regain their energy and strength.

Radiotherapy
Patients whose cancer has progressed too far for surgery (Stages III and IV) may receive radiotherapy.
Radiotherapy involves the use of high-energy rays to kill cancer cells. It is used either by itself or in combination with surgery or chemotherapy. The amount of radiation used depends on the size and the location of the tumor.

Radiation therapy may produce such side effects as fatigue, skin rashes, upset stomach, and diarrhea. Dry or sore throats, difficulty in swallowing, and loss of hair (alopecia) in the treated area are all minor side effects of radiation. These may disappear either during the course of the treatment or after the treatment is over.

Chemotherapy
Chemotherapy is also given to patients whose cancer has progressed too far for surgery. Chemotherapy is medication that is usually given intravenously to kill cancer cells. These drugs enter the bloodstream and travel to all parts of the body, killing cancer cells that have spread to different organs. Chemotherapy is used as the primary treatment for cancers that have spread beyond the lung and cannot be removed by surgery. It can also be used in addition to surgery or radiation therapy.

Chemotherapy is tailored to each patient’s needs.

Most patients are given a combination of several different drugs. Because these drugs also harm normal cells, doses are carefully adjusted. Chemotherapy often has severe side effects, including nausea and vomiting, hair loss, anemia, weakening of the immune system, and sometimes infertility. Most of these side effects end when the treatment is over. Other medications can be given to lessen the unpleasant side effects of chemotherapy.

Prognosis
The prognosis for non-small cell lung cancer is better if the disease is found early, and removed surgically.

For patients whose disease is caught in Stage I, the survival rate five years after surgery ranges from 60% to 80%. Up to 55% of Stage II patients are alive after five years, but only about 30% of Stage III patients survive five years. Unfortunately, 85% of patients already have at least Stage III cancer by the time they are diagnosed.

Many of these patients have disease that is too advanced for surgery. Despite treatment with radiotherapy and chemotherapy, the five-year survival for patients with inoperable disease is extremely low.

Alternative and complementary therapies
Because non-small cell lung cancer has a poor prognosis with conventional medical treatment, many patients are willing to try complementary and alternative therapies.

These therapies are used to try to reduce stress, ease side effects and symptoms, or control disease. Two treatments sometimes used are shark cartilage and mistletoe. Although shark cartilage is thought to interfere with the tumor’s blood supply, clinical trials have so far been inconclusive.

Mistletoe is a poisonous plant that has been shown to kill cancer cells in the laboratory. Again, however, clinical trials with cancer patients have been inconclusive.
Patients who decide to try complementary and alternative therapies should tell their doctor. Some of these therapies may interfere with conventional treatment.

Coping with cancer treatment
The side effects associated with treatment of nonsmall cell lung cancer can be severe. Patients should ask their doctor about medications to treat nausea and vomiting, and other side effects. It is particularly important to eat a nutritious diet and to drink plenty of fluids. In addition, most patients report feeling very tired and should get plenty of rest.
Patients should consider joining a local support group with people who are coping with the same experiences.

Many people with cancer find they can share thoughts and feelings with group members that they do not feel comfortable sharing with friends or family. Support groups are also a good source of information about coping with cancer.

Clinical trials
Patients diagnosed with non-small cell lung cancer should discuss participating in a clinical trial with their doctor. There are many clinical trials currently underway that are investigating all different stages of the disease.
These trials are studying various new treatment options including:

• Chemotherapy with new drugs, and combinations of drugs
• Courses of chemotherapy prior to surgery
• Radiotherapy after surgery
• Chemotherapy and radiotherapy in combination.

Information on open clinical trials is available on the Internet from the National Cancer Institute at http://cancertrials.nci.nih.gov.

Prevention
The best way to prevent lung cancer is not to start smoking or to quit smoking. Secondhand smoke from other people’s tobacco should also be avoided. Appropriate precautions should be taken when working with cancer-causing substances (carcinogens). Testing houses for the presence of radon gas, and removing asbestos from buildings have also been suggested as preventive strategies.

Special concerns

Respiratory distress
Patients who are having difficulty breathing because
of non-small cell lung cancer are often unable to get enough oxygen and suffer from respiratory distress.

These patients may begin breathing more quickly and wheezing. Patients will usually be given oxygen and medications such as morphine that will help them breathe more easily.

Follow-up
Regular checkups after treatment for non-small cell lung cancer are extremely important. Patients who have been treated for lung cancer should report any health problems to their doctor immediately to ensure quick treatment if the cancer has returned.

Resources
BOOKS
Brambilla, Christian, and Elisabeth Brambilla, ed. Lung Tumors. Fundamental Biology and Clinical Management.
New York: Marcel Dekker, 1999. Skarin, Harry S., ed. Multimodality Treatment of Lung Cancer. New York: Marcel Dekker, 2000.

PERIODICALS
Carney, Desmond N., and Heine H. Hansen. “Non-Small-Cell Lung Cancer: Stalemate or Progress?” New England Journal of Medicine 343, no. 17 (26 October 2000): 1261–3. Deslauriers, Jean, and Jocelyn Gregoire. “Clinical and Surgical Staging of Non-Small Cell Lung Cancer.” Chest 117, no. 4, supplement 1 (April 2000): 96S–103S.

Hoffman, Phillip C., et al. “Lung Cancer.” The Lancet (355) (5 February 2000): 479–85.

Johnson, David H. “Locally Advanced, Unresectable Non-Small Cell Lung Cancer. New Treatment Strategies.”
Chest 117, no.4, supplement 1 (April 2000): 123S–126S.

ORGANIZATIONS
Alliance for Lung Cancer Advocacy, Support and Education.PO Box 849 Vancouver,WA 98666. (800) 298-2436.
http://www.alcase.org.

American Lung Association. (800) 586-4872. http://www.lungusa.org.

National Cancer Institute (National Institutes of Health). 9000 Rockville Pike, Bethesda, MD 20892. (800) 422-6237. http://www.nci.nih.gov

National Center for Complementary and Alternative Medicine
(National Institutes of Health). PO Box 8218, Silver Spring, MD 20907-8218. (888) 644-6226. http://nccam.nih.gov.

Lata Cherath, Ph.D
Alison McTavish, M.Sc.

Diseases and Conditions Center

All ArmMed Media material is provided for information only and is neither advice nor a substitute for proper medical care. Consult a qualified healthcare professional who understands your particular history for individual concerns.