Until now,no sufficient Literature data exist about combined hormonal contraceptives delivered by a different route (transdermal patch, vaginal ring, subdermal implant ).

Instead, a cohort study reported no stroke relief among 49,048 women-years of transdermal contraceptive system exposure,  and 10 among   norgestimate-containing   oral   contraceptive   users   ⁽⁴⁴⁾.

In   conclusion, current available studies indicate that there is no significant increase in the risk of ischaemic stroke or acute myocardial infarction associated with the use of low-dose estrogen COCs in women properly screened before use,  and who have no pre-existing cardiovascular risk factors.

—
Rosa Sabatini and Giuseppe Loverro
Dept. Obstetrics and Gynecology,
General Hospital Policlinico-University of Bari, Italy

—

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