A new study supports the theory that the detrimental effects of low-level exposure to mercury may be outweighed by the beneficial effects of fish consumption.

The study finds little evidence of harm in infants whose mothers had low fish consumption and low mercury exposure. In fact, infants of mothers with higher mercury exposure during pregnancy and who consumed more fish had better attention and needed less special handling during a newborn exam. This likely was due to the beneficial nutritional effects of fish consumption, according to the researchers.

“The better neurobehavioral performance observed in infants with higher mercury biomarkers should not be interpreted as a beneficial effect of mercury exposure, which is clearly neurotoxic,” says Kim Yolton, PhD, a researcher at Cincinnati Children’s Hospital Medical Center and senior author of the study. “It likely reflects the benefits of polyunsaturated fatty acid intake that also comes from fish and has been shown to benefit attention, memory, and other areas of development in children. In our study, mercury exposure was very low, primarily due to consumption of fish low in mercury, so the detrimental effects might have been outweighed by the beneficial effects of fish nutrition.”

The study is published online in Neurotoxicology and Teratology.

The researchers assessed the neurobehavior of 344 5-week-old infants using a standard neurobehavioral scale. Gestational mercury exposure was measured in maternal blood and infant umbilical cord blood. The researchers collected fish consumption information from the mothers and estimated polyunsaturated fatty acid intake based on the type and amount of fish consumed.

Eighty-four percent of mothers reported eating fish during pregnancy but only about two ounces per week on average. Those infants with higher prenatal mercury exposure showed asymmetric, or unequal reflexes. But when fish consumption was taken into account, those whose mothers consumed more fish had better attention and needed less special handling.

In 2014, the FDA and EPA updated their advice to consumers to encourage women to eat more fish (eight to 12 ounces per week) than had previously been recommended and to select fish with the lowest mercury levels. These include salmon, shrimp, pollock, light canned tuna, tilapia, catfish, and cod. They also suggested avoiding fish with the highest mercury levels, including tilefish, shark, swordfish, and mackerel.

“The important thing for women to remember is that fish offers excellent nutritional qualities that can benefit a developing baby or young child,” says Dr. Yolton. “Moms just need to be thoughtful about which fish they eat or provide to their child.”

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The study was funded by grants from the National Institute of Environmental Health Sciences and Environmental Protection Agency (R01 ESO15517, P01 ES11261).

About Cincinnati Children’s

Cincinnati Children’s Hospital Medical Center ranks third in the nation among all Honor Roll hospitals in U.S.News and World Report’s 2015 Best Children’s Hospitals. It is also ranked in the top 10 for all 10 pediatric specialties, including a #1 ranking in pulmonology and #2 in cancer and in nephrology. Cincinnati Children’s, a non-profit organization, is one of the top three recipients of pediatric research grants from the National Institutes of Health, and a research and teaching affiliate of the University of Cincinnati’s College of Medicine. The medical center is internationally recognized for improving child health and transforming delivery of care through fully integrated, globally recognized research, education and innovation.

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Journal
  Neurotoxicology and Teratology

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Jim Feuer
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