New research reports that liver transplant recipients who receive substance abuse treatment before and after transplantation have much lower alcohol relapse rates than those untreated or only treated prior to transplantation. A second study determines that continued alcohol abuse following liver transplantation decreases graft survival, further highlighting the importance of preventing alcohol relapse. Both studies are published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) estimates that nearly 23% of women and 42% of men, 18 years of age and older in the U.S., drank alcohol at least once a week or more in the previous year. Moreover, the Centers for Disease Control and Prevention (CDC), report that 51.5% of Americans 18 and over were regular drinkers, consuming at least 12 alcoholic beverages in the past year.

Medical evidence shows that alcoholic liver disease (ALD) is the second most common reason for liver transplantation in the U.S. and Europe. Prior research indicates that survival rates following transplantation for ALD are comparable to those for patients without ALD. However, relapse of substance abuse post-transplant is not unusual with rates ranging from 10% to 90%.

A team led by James Rodrigue, Ph.D. with The Transplant Institute at Beth Israel Deaconess Medical Center in Boston, Mass examined 118 liver transplant recipients - 52% with a history of alcohol abuse having received substance abuse treatment prior to transplantation. Findings indicate that alcohol relapse was 16% among liver transplant recipients who had substance abuse treatment before and after transplantation. In patients who received pre-transplant or no substance abuse treatment the relapse rates were 45% and 41%, respectively.

“While many transplant centers require candidates with a history of alcohol abuse to attend substance abuse treatment prior to transplantation, our findings emphasize the importance of continued therapy after the transplant to prevent alcohol relapse,” said Dr. Rodrigue.

A related study also published in Liver Transplantation found that excessive drinking - alcohol use without any periods of sobriety - post-transplantation for ALD is associated with decreased graft survival and increased organ scarring (fibrosis). Lead investigator, Dr. John Rice from the University of Wisconsin School of Medicine and Public Health said, “Our study highlights the need for ongoing assessments of alcohol use as part of post-transplant care. Given the shortage of available donor livers, maintaining sobriety is critical to maximizing organ use and patient outcomes following transplantation.”

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These studies are published in Liver Transplantation. Media wishing to receive a PDF of the articles may contact .(JavaScript must be enabled to view this email address).

Full citations: “Substance Abuse Treatment and Its Association with Relapse to Alcohol Use Following Liver Transplantation.” James R. Rodrigue, Douglas W. Hanto and Michael P. Curry. Liver Transplantation; (DOI: 10.1002/lt.23747) Published Online: October 1, 2013.

“Abusive Drinking Post-Liver Transplant is Associated with Allograft Loss and Advanced Allograft Fibrosis.” John P. Rice, Jens Eickhoff, Rashmi Agni, Aiman Ghufran, Rinjal Brahmbhatt and Michael R. Lucey. Liver Transplantation; (DOI: 10.1002/lt.23762) Published Online: October 1, 2013.

Author Contact: Media wishing to speak with Dr. Rodrigue may contact Jerry Berger with Beth Israel Deaconess Medical Center at .(JavaScript must be enabled to view this email address). To speak with Dr. Rice, please contact Gian Galassi at the UW Transplantation office at .(JavaScript must be enabled to view this email address)

About the Journal

Liver Transplantation is published by Wiley on behalf of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. Since the first application of liver transplantation in a clinical situation was reported more than twenty years ago, there has been a great deal of growth in this field and more is anticipated. As an official publication of the AASLD and the ILTS, Liver Transplantation delivers current, peer-reviewed articles on surgical techniques, clinical investigations and drug research - the information necessary to keep abreast of this evolving specialty.

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