Nonprescription pain relievers are analgesics that can be bought without a doctor’s order (prescription). Sometimes they are called “over-the-counter” pain remedies. They include aspirin (Bufferin, Ascriptin, Ecotrin), acetaminophen (Anacin-3, Tylenol, Datril), and ibuprofen (Advil, Motrin, Nuprin). Many nonprescription pain relievers have different names, but if you check the labels, nearly all contain one of these three medicines. They are effective for relief of mild and moderate pain.

What’s the Difference Between a Brand Name Drug and a Generic Drug?
Drugs are complex substances, and they may have as many as three different names: chemical, generic, and brand. Chemical names are long and difficult to pronounce. The U.S. Food and Drug Administration approves the generic, shortened names by which drugs are usually known. Drug companies give their products brand names. For example N-(4-hydroxyphenyl) acetamide is the chemical name for acetaminophen, which is the generic name for Tylenol. Many nonprescription and prescription pain relievers are available under both generic and brand names. Your doctor or pharmacist can tell you the generic name. Generic products tend to be less expensive than brand-name drugs and usually are just as effective. However, because of differences in manufacturing methods, medicines with the same generic name produced by different companies may differ in the way they are absorbed by the body. For this reason, your doctor may prefer that you take a brand-name drug. You might want to ask your doctor or pharmacist if you can use a less expensive medication. Pharmacies are careful to obtain high-quality generic products, so it is sometimes possible to make substitutions.

Are Aspirin, Acetaminophen, and Ibuprofen Different?
Yes. Each is a different chemical. They all have similar pain-relieving effects, but they have some important differences:

 
• Aspirin and ibuprofen reduce inflammation; acetaminophen does not.  
• Aspirin and ibuprofen are often used to reduce the pain of swollen joints and other inflamed areas; acetaminophen is not.  
• Aspirin and ibuprofen can irritate the stomach. Sometimes they even cause stomach bleeding. Acetaminophen does not have this effect.  
• Aspirin and ibuprofen can affect blood clotting and may cause bleeding. Acetaminophen has no effect on blood clotting.  
• When aspirin is used to treat children with viral diseases such as the flu or chickenpox, it may cause Reye’s syndrome, a rare brain and liver disease. Acetaminophen and ibuprofen do not cause Reye’s syndrome.  
• Ibuprofen can make existing kidney problems worse. In normal doses, aspirin and acetaminophen usually do not injure the kidneys.

Are There Reasons I Should Not Take Aspirin?
Although aspirin is a very common medicine, it should not be used by everyone. Before you take aspirin in any form, ask your doctor or nurse if there is any reason for you not to take it. Some people have conditions that may be made worse by aspirin or by any product that contains aspirin. In general, aspirin should be avoided by people who:

 
• Are on anticancer drugs that may cause bleeding.  
• Are on steroid medicines such as prednisone.  
• Will have surgery within a week.  
• Are allergic to aspirin.  
• Are taking blood-thinning medicine (anticoagulants such as Coumadin).  
• Have stomach ulcers or a history of ulcers, gout, or bleeding disorders.  
• Are taking prescription drugs for arthritis.  
• Are taking oral medicines for diabetes or gout.

Be careful about mixing aspirin with alcohol - taking aspirin and drinking alcohol on an empty stomach can cause stomach upset and internal bleeding.

Is There Aspirin in Any Other Medicine?
Yes. If your doctor does not want you to take aspirin, be sure to read labels carefully. Many nonprescription products contain “hidden” aspirin. For example, aspirin is in Excedrin (a pain reliever) and Alka-Seltzer (an antacid). Some prescription pain relievers, such as Percodan and Empirin Compound with Codeine, also contain aspirin. If you are not sure if your prescription contains aspirin, ask your pharmacist.

What Are the Side Effects From Aspirin?
The most common side effect from aspirin is stomach upset or indigestion. Taking aspirin with food lessens the chance of this side effect. If aspirin upsets your stomach, you can use buffered aspirin or coated aspirin. Ask your pharmacist to tell you which aspirin products are less likely to upset your stomach. When some people take aspirin for long periods of time they may notice:

 
• Ringing in the ears or hearing loss.  
• Unusual sweating.  
• Headache, dizziness, dimness of vision, confusion, fever, or drowsiness.  
• Rapid breathing and rapid heartbeat.  
• Thirst, nausea, vomiting, or diarrhea.

If you notice these symptoms, check with your doctor right away. Aspirin also can cause internal bleeding, which usually is painless. If your stools become darker than normal or you notice unusual bruising, tell your doctor or nurse. These can be signs of internal bleeding.

Are There Side Effects From Acetaminophen Or Ibuprofen?
People rarely have any side effects from the usual dose of acetaminophen. However, liver or kidney damage may result from using large doses of this drug every day for a long time or drinking large amounts of alcohol with the usual dose. Serious side effects from ibuprofen are uncommon. Some people notice that it upsets the stomach. When it is used for long periods of time or when it is used by patients taking steroid medications, there is an increased risk of stomach bleeding. If you have kidney problems, ibuprofen may make them worse. And, because it may interfere with the ability of blood to clot, it may be dangerous for patients with low platelet counts.

How Many Aspirin Or Acetaminophen Tablets Can I Take At One Time and How Many Can I Take During an Entire Day? What About Ibuprofen?
The doses of these pain relievers are different for different people. Some people get the best pain relief when they take a small dose every 3 hours. Other people may find that a larger dose taken less frequently works for them. You should not take a larger dose than the label tells you without first checking with your doctor, nurse, or pharmacist.

Aspirin: The usual safe dose of aspirin for adults is two or three tablets (325 mg or 5 grains each) taken three or four times a day. A total of eight adult aspirins a day usually does not produce any major side effects. Many adults can safely take a total of 12 tablets a day. Any dose higher than 12 a day, however, should be taken only with your doctor’s or nurse’s advice.
Acetaminophen: The usual safe dose of acetaminophen for adults is 2 or 3 tablets (325 mg or 5 grains each) taken three or four times a day, for a total of 8 to 12 tablets a day. Extra-strength forms, such as extra-strength Tylenol are equal to 1 regular tablets (500 mg or 7 grains each); you should take no more than 8 of these tablets in 24 hours.
Ibuprofen: The usual dose of ibuprofen for adults is 1 tablet (200 mg each) every 4 to 6 hours. You should not take more than 6 tablets in 24 hours. Larger doses should only be taken if they are prescribed by your doctor.

How Long Does It Take the Medicines To Work and How Long Does Pain Relief Last?
The effect of aspirin begins 30 to 60 minutes after you take it. (Coated aspirin may need 1 to 8 hours to work.) The pain-relieving action of one dose usually lasts about 4 hours but may last up to 12 hours. Acetaminophen relieves pain within 10 to 60 minutes of taking it. Its effect may last up to 6 hours. Ibuprofen begins to relieve pain in 1 to 2 hours and lasts from 5 to 10 hours. You may need to take ibuprofen for 2 to 3 days before you get the most pain relief.

There Are So Many Nonprescription Pain Relievers Available. What Are the Differences Among Them?
Drugstore shelves are filled with many pain remedies. Each one is advertised to be better and faster acting than the others. But nearly all nonprescription pain relievers rely on aspirin, acetaminophen, or ibuprofen for pain relief. Some brands also contain substances called additives. Common ones include the following:

 
• Buffers (e.g., magnesium carbonate, aluminum hydroxide) to decrease stomach upset.  
• Caffeine to act as a stimulant and lessen pain.  
• Antihistamines (e.g., diphenhydramine, pyrilamine) to help you relax or sleep.

Combination products have some disadvantages. The additives can produce undesirable effects. For example, antihistamines sometimes cause drowsiness. You may find this acceptable at bedtime, but it could be a problem during the day or while driving. In addition, additives tend to increase the cost of nonprescription pain relievers. They also can change the action of other medicines you may be taking. Plain aspirin, acetaminophen, or ibuprofen are probably as effective as any combination product. But if you find that a brand with certain additives is a better pain reliever for you, ask your doctor, nurse, or pharmacist if the additives are safe for you. If you have any questions about the drugs contained in your nonprescription analgesics, ask your doctor, nurse, or pharmacist.

Why Should I Take Nonprescription Medicines For My Pain? Aren’t There Stronger, More Effective Pain Relievers?
In many cases, the nonprescription medicines are all you will need to relieve your pain, especially if you stay on top of the pain by taking them on a regular, preventive basis. These medicines are stronger analgesics than most people realize. Certain doses of prescription pain relievers given by mouth are no more effective than two or three regular tablets of aspirin, acetaminophen, or ibuprofen. Research has shown that for most people the usual dose of nonprescription pain relievers provides as much pain relief as prescription medications such as codeine or Darvon. If you get pain relief from nonprescription medicines, you do not need to take prescription pain relievers. For most people, nonprescription pain relievers have fewer side effects than prescription pain relievers.

Can I Take Nonprescription Pain Relievers If My Doctor Has Also Prescribed Stronger Analgesics?
You should discuss this question with your doctor or nurse. Many people who need prescription analgesics also can benefit from continuing to take regular doses of aspirin, acetaminophen, or ibuprofen. The nonprescription analgesics and the stronger prescription medicines relieve pain in different ways. When you take both of them, your pain is attacked on two different levels. Aspirin, acetaminophen, or ibuprofen taken four times a day might help reduce the amount of stronger pain reliever you need. Some prescription pain tablets contain aspirin or acetaminophen. Ask your pharmacist or doctor how much aspirin or acetaminophen, if any, is in your prescription. A nurse, doctor, or pharmacist can help you figure out how much aspirin or acetaminophen you can safely add.